Regulation of Cardiovascular Signaling by Kinins and Products of Similar Converting Enzyme Systems Decreased renal NO excretion and reduced glomerular tuft area in mice lacking the bradykinin B2 receptor
نویسندگان
چکیده
Joost P. Schanstra,1 Johan Duchene,1 Françoise Praddaude,1 Patrick Bruneval,2 Ivan Tack,1 Jacques Chevalier,2 Jean-Pierre Girolami,1 and Jean-Loup Bascands1 1Institut National de la Santé et de la Recherche Médicale U388, Institut Louis Bugnard, Centre Hospitalier Universitaire Rangueil, 31052 Toulouse; 2Institut National de la Santé et de la Recherche Médicale U430, Hôpital Broussais, 75674 Paris Cedex 14, France
منابع مشابه
Decreased renal NO excretion and reduced glomerular tuft area in mice lacking the bradykinin B2 receptor.
Bradykinin B(2) receptor knockout mice (B(2)-/-) have been useful to study the role of bradykinin under pathological conditions. With the use of these mice, it was shown that bradykinin plays an important role in angiogenesis, heart failure, salt-induced hypertension, and kidney fibrosis. Data on the role of the bradykinin B(2) receptor under physiological conditions using these mice are contro...
متن کاملAFLUID March 47/3
Wang, Danzhao, Hideaki Yoshida, Qing Song, Lee Chao, and Julie Chao. Enhanced renal function in bradykinin B2 receptor transgenic mice. Am. J. Physiol. Renal Physiol. 278: F484–F491, 2000.—The tissue kallikrein-kinin system has been recognized as a paracrine and/or autocrine hormonal system that regulates arterial pressure, renal hemodynamics, and electrolyte excretion. We have created a transg...
متن کاملRegulation of Cardiovascular Signaling by Kinins and Products of Similar Converting Enzyme Systems Changes in amino-terminal portion of human B2 receptor selectively increase efficacy of synthetic ligand HOE 140 but not of cognate ligand bradykinin
Christian Schroeder,1 Andreas Breit,2,5 Hilke Böning,3,5 Jürgen Dedio,2,4 Lajos Gera,6 John Stewart,6 and Werner Müller-Esterl2 1Institute for Cardiovascular and Arteriosclerosis Research, Bayer D-42096, Wuppertal; 2Institute for Biochemistry II, The University of Frankfurt Medical School, D-60590 Frankfurt; 3Department of Biochemistry, University of Münster, D-48419 Münster; 4Aventis, Disease ...
متن کاملRegulation of Cardiovascular Signaling by Kinins and Products of Similar Converting Enzyme Systems Kininase I-type carboxypeptidases enhance nitric oxide production in endothelial cells by generating bradykinin B1 receptor agonists
Sangsree, Sakonwun, Viktor Brovkovych, Richard D. Minshall, and Randal A. Skidgel. Kininase I-type carboxypeptidases enhance nitric oxide production in endothelial cells by generating bradykinin B1 receptor agonists. Am J Physiol Heart Circ Physiol 284: H1959–H1968, 2003. First published March 6, 2003; 10.1152/ajpheart.00036.2003. Kininase I-type carboxypeptidases convert native kinin agonists ...
متن کاملEnhanced renal function in bradykinin B(2) receptor transgenic mice.
The tissue kallikrein-kinin system has been recognized as a paracrine and/or autocrine hormonal system that regulates arterial pressure, renal hemodynamics, and electrolyte excretion. We have created a transgenic mouse model overexpressing human bradykinin B(2) receptor, and the mice developed lifetime hypotension. With this animal model, we further analyzed the potential role of B(2) receptors...
متن کامل